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KMID : 1141920210370020120
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Annals of Coloproctology
2021 Volume.37 No. 2 p.120 ~ p.124
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An Unusual Case of Colon Perforation With Multiple Transmural Ulcers After Use of Polmacoxib and Everolimus in a Metastatic Breast Cancer Patient
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Song In-Gyu
Jung Kyung-Uk
Kim Hyung-Ook
Kim Hung-Dai
Chun Ho-Kyung
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Abstract
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Everolimus (Afinitor) is an inhibitor of mammalian target of rapamycin. Polmacoxib (Acelex) is a nonsteroidal anti-inflammatory drug that belongs to the cyclooxygenase-2 (COX-2) inhibitor family and is mainly used for treatment of arthritis. Intestinal perforation has not been reported previously as a complication of everolimus, and perforation of the lower intestinal tract caused by a selective COX-2 inhibitor is extremely rare. We present here a case of colon perforation that occurred after use of polmacoxib in a metastatic breast cancer patient who had been treated with everolimus for the preceding six months.
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KEYWORD
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Colon perforation, Everolimus, mTOR inhibitor, Polmacoxib, Nonsteroidal anti-inflammatory agents
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